Tìm theo
ACCLAIM
Thuốc Gốc
Small Molecule
CTHH: C18H16ClNO5
PTK: 361.776
ACCLAIM (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic shown to induce coronary vasodilation while overcoming the significant problem of drug tolerance. ACCLAIM treat chronic angina, the chest pain that occurs from inadequate blood flow to the coronary arteries around the heart.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H16ClNO5
Phân tử khối
361.776
Monoisotopic mass
361.071700334
InChI
InChI=1S/C18H16ClNO5/c1-3-22-17(21)11(2)23-13-5-7-14(8-6-13)24-18-20-15-9-4-12(19)10-16(15)25-18/h4-11H,3H2,1-2H3
InChI Key
InChIKey=PQKBPHSEKWERTG-UHFFFAOYSA-N
IUPAC Name
ethyl 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}propanoate
Traditional IUPAC Name
fenoxaprop-ethyl
SMILES
CCOC(=O)C(C)OC1=CC=C(OC2=NC3=C(O2)C=C(Cl)C=C3)C=C1
Độ hòa tan
2.73e-02 g/l
logP
4.5
logS
-4.1
pKa (Strongest Basic)
-2.9
PSA
70.79 Å2
Refractivity
89.8 m3·mol-1
Polarizability
36.68 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Cơ Chế Tác Dụng : ACCLAIM (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic shown to induce coronary vasodilation while overcoming the significant problem of drug tolerance. ACCLAIM treat chronic angina, the chest pain that occurs from inadequate blood flow to the coronary arteries around the heart. ACCLAIM is a proprietary combination of nitrate and L-arginine that provides the beneficial cardiovascular effects of nitrates. Combining L-arginine with organic nitrates prevents the endothelial cell's depletion of L-arginine and the associated problem of nitrate tolerance. By eliminating nitrate tolerance, ACCLAIM allows patients to receive the continuous, 24-hour benefit of a potent nitrate product, thus sustaining the desired vasodilation effect.
Chỉ Định : Chronic angina and Coronary Artery Disease
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05252
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=47938
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=192343
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11024
ChemSpider
http://www.chemspider.com/Chemical-Structure.43609.html
... loading
... loading