AC220

Thuốc điều trị ung thư

Thuốc Gốc

Small Molecule

CAS: 26590-20-5

AC220 is a small-molecule, potent inhibitor of FLT3.

Dược Lực Học : In preclinical studies, AC220 demonstrated dose-dependent activity and favorable drug-like profiles in bioavailability, pharmacokinetics, cytochrome P450 (CYP) liability, and absorption, distribution, metabolism, excretion (ADME).

Cơ Chế Tác Dụng : AC220 is a small-molecule, potent inhibitor of FLT3. AC220 potently inhibits FLT3, a kinase that is mutated in approximately one-third of acute myeloid leukemia cases, and patients with FLT3 mutations are less responsive to traditional therapies.

Chỉ Định : For the treatment of Acute Myeloid Leukemia (AML).

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB05213

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