Tìm theo
AC220
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 26590-20-5
AC220 is a small-molecule, potent inhibitor of FLT3.
Dược Lực Học : In preclinical studies, AC220 demonstrated dose-dependent activity and favorable drug-like profiles in bioavailability, pharmacokinetics, cytochrome P450 (CYP) liability, and absorption, distribution, metabolism, excretion (ADME).
Cơ Chế Tác Dụng : AC220 is a small-molecule, potent inhibitor of FLT3. AC220 potently inhibits FLT3, a kinase that is mutated in approximately one-third of acute myeloid leukemia cases, and patients with FLT3 mutations are less responsive to traditional therapies.
Chỉ Định : For the treatment of Acute Myeloid Leukemia (AML).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05213
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