Tìm theo
AC-1202
Thuốc Gốc
Small Molecule
AC-1202 is a first-in-class therapeutic that targets neuronal cells in the brain and acts to increase mitochondrial activity. Numerous studies have shown that energy metabolism and lipid homeostasis are impaired in neuronal cells within the hippocampal region of the brain where memory and cognition are processed. Research has shown that AC-1202 lowers oxidative stress in the brain while increasing energy metabolism essential for the synthesis of key neurotransmitters and lipids. Preclinical studies of AC-1202 have shown it to be effective in behavioral studies of learning and memory, and a Phase IIa clinical trial demonstrated that it improved certain measures of memory in Alzheimer's disease patients.
Cơ Chế Tác Dụng : AC-1202 is a first-in-class therapeutic that targets neuronal cells in the brain and acts to increase mitochondrial activity. Numerous studies have shown that energy metabolism and lipid homeostasis are impaired in neuronal cells within the hippocampal region of the brain where memory and cognition are processed. Research has shown that AC-1202 lowers oxidative stress in the brain while increasing energy metabolism essential for the synthesis of key neurotransmitters and lipids. Preclinical studies of AC-1202 have shown it to be effective in behavioral studies of learning and memory, and a Phase IIa clinical trial demonstrated that it improved certain measures of memory in Alzheimer's disease patients. AC-1202 is an orally available, liquid compound that is efficiently converted by the liver into ketone bodies, an alternative energy source that the brain can metabolize even when it cannot process glucose. Thus preserving the glucose- deprived brain cells, AC-1202 has disease modifying potential in AD and a number other neurodegenerative diseases characterized by neuronal hypometabolism.
Chỉ Định : Investigated for use/treatment in memory loss.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ketasyn
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05781
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