Tìm theo
ABT-089
Thuốc Gốc
Small Molecule
CTHH: C11H16N2O
PTK: 192.2575
ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for the treatment of several neurological disorders including Alzheimer, Attention Deficit Hyperactivity Disorder and Schizophrenia/Schizoaffective disorders. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes. Neuronal nicotinic acetylcholine receptors (nAChRs) modulate the release of several important neurotransmitters, such as acetylcholine and dopamine.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H16N2O
Phân tử khối
192.2575
Monoisotopic mass
192.126263144
InChI
InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1
InChI Key
InChIKey=YRVIKLBSVVNSHF-JTQLQIEISA-N
IUPAC Name
2-methyl-3-[(2S)-pyrrolidin-2-ylmethoxy]pyridine
Traditional IUPAC Name
pozanicline
SMILES
CC1=C(OC[C@@H]2CCCN2)C=CC=N1
Độ hòa tan
1.31e+01 g/l
logP
0.83
logS
-1.2
pKa (Strongest Basic)
10.47
PSA
34.15 Å2
Refractivity
54.89 m3·mol-1
Polarizability
21.74 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : ABT-089 is a neuronal nicotinic acetylcholine receptor agonist. Neuronal nicotinic acetylcholine receptors (nAChRs) modulate the release of several important neurotransmitters, such as acetylcholine and dopamine.
Cơ Chế Tác Dụng : ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for the treatment of several neurological disorders including Alzheimer, Attention Deficit Hyperactivity Disorder and Schizophrenia/Schizoaffective disorders. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes. Neuronal nicotinic acetylcholine receptors (nAChRs) modulate the release of several important neurotransmitters, such as acetylcholine and dopamine. ABT-089 is a neuronal nicotinic acetylcholine receptor agonist. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes.
Độc Tính : ABT-089 was shown to be well-tolerated in clinical trials.
Chỉ Định : Investigated for use/treatment in Alzheimer's disease, Attention Deficit/Hyperactivity Disorder (ADHD), and Schizophrenia and schizoaffective disorders.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05458
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=178052
ChemSpider
http://www.chemspider.com/Chemical-Structure.155000.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056147
... loading
... loading