Tìm theo
8-azaguanine
Các tên gọi khác (5 ) :
  • Azaguanine
  • Azaguanine-8
  • Guanazol
  • Pathocidin
  • Pathocidine
antimetabolites antineoplastic
Thuốc Gốc
Small Molecule
CAS: 134-58-7
CTHH: C4H4N6O
PTK: 152.1142
One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C4H4N6O
Phân tử khối
152.1142
Monoisotopic mass
152.04465878
InChI
InChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
InChI Key
InChIKey=LPXQRXLUHJKZIE-UHFFFAOYSA-N
IUPAC Name
5-amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
Traditional IUPAC Name
5-amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
SMILES
NC1=NC2=C(NN=N2)C(O)=N1
Độ tan chảy
300 °C
Độ hòa tan
Insoluble
logP
-0.71
logS
-1.4
pKa (strongest acidic)
7.89
pKa (Strongest Basic)
0.05
PSA
113.6 Å2
Refractivity
39.24 m3·mol-1
Polarizability
12.62 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
6
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01667
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50200096
Wikipedia
http://en.wikipedia.org/wiki/8-Azaguanine
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