Tìm theo
7a-methyl-19-nortestosterone
contraceptives postcoital hormonal
Thuốc Gốc
Small Molecule
CTHH: C19H28O2
PTK: 288.4244
Trestolone (7α-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces a state of temporary infertility.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H28O2
Phân tử khối
288.4244
Monoisotopic mass
288.20893014
InChI
InChI=1S/C19H28O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h10-11,14-18,21H,3-9H2,1-2H3/t11-,14?,15?,16?,17?,18?,19?/m1/s1
InChI Key
InChIKey=YSGQGNQWBLYHPE-BRIGUCEYSA-N
IUPAC Name
(9R)-14-hydroxy-9,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional IUPAC Name
(9R)-14-hydroxy-9,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
SMILES
C[C@@H]1CC2=CC(=O)CCC2C2CCC3(C)C(O)CCC3C12
Độ hòa tan
3.91e-02 g/l
logP
3.35
logS
-3.9
pKa (strongest acidic)
19.38
pKa (Strongest Basic)
-0.88
PSA
37.3 Å2
Refractivity
84.5 m3·mol-1
Polarizability
33.93 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Trestolone (7α-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces a state of temporary infertility. Spermatozoa are produced in the testes of males in a process called spermatogenesis. In order to render a man infertile, a hormone-based male contraceptive method must stop spermatogenesis by interrupting the release of gonadotropins from the pituitary gland. Even in low concetrations, trestolone is a potent inhibitor of the release of the gonadotropin hormones, luteinizing hormone (LH) and follicle stimulating hormone (FSH). In order for spermatogenesis to occur in the testes, both FSH and the male hormone testosterone must be present. By inhibiting release of FSH, trestolone creates an endocrine environment in which conditions for spermatogenesis are not ideal. Manufacture of sperm is further impaired by the suppression of LH, which in turn drastically cutails the production of testosterone. Sufficient regular doses of trestolone cause severe oligozoospermia or azoospermia, and therefore infertility, in most male patients.
Chỉ Định : Investigated for use/treatment in contraception and male hormonal deficiencies/abnormalities.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : MENT
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05830
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=19582
ChemSpider
http://www.chemspider.com/Chemical-Structure.18447.html
Wikipedia
http://en.wikipedia.org/wiki/MENT
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