Tìm theo
5-Fluorouridine
Các tên gọi khác (4 ) :
  • 5-Fluoro-uridine
  • 5-Fluorouracil 1beta-D-ribofuranoside
  • 5-Fur
  • FUrd
Thuốc Gốc
Small Molecule
CAS: 316-46-1
CTHH: C9H11FN2O6
PTK: 262.1918
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H11FN2O6
Phân tử khối
262.1918
Monoisotopic mass
262.060114299
InChI
InChI=1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
InChI Key
InChIKey=FHIDNBAQOFJWCA-UAKXSSHOSA-N
IUPAC Name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
Traditional IUPAC Name
5-fluorouridine
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=C(F)C(=O)NC1=O
Độ tan chảy
182 °C
Độ hòa tan
6.07e+01 g/l
logP
-2.2
logS
-0.64
pKa (strongest acidic)
7.67
pKa (Strongest Basic)
-3
PSA
119.33 Å2
Refractivity
52.77 m3·mol-1
Polarizability
21.9 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
6
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01629
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9427
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504520
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C16633
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