Tìm theo
3-Methylthiofentanyl
Các tên gọi khác (1) :
  • 3-Methyl-thiofentanyl
Thuốc Gốc
Small Molecule
CAS: 86052-04-2
CTHH: C21H28N2OS
PTK: 356.525
3-Methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H28N2OS
Phân tử khối
356.525
Monoisotopic mass
356.192234218
InChI
InChI=1S/C21H28N2OS/c1-3-21(24)23(18-8-5-4-6-9-18)20-12-14-22(16-17(20)2)13-11-19-10-7-15-25-19/h4-10,15,17,20H,3,11-14,16H2,1-2H3
InChI Key
InChIKey=SRARDYUHGVMEQI-UHFFFAOYSA-N
IUPAC Name
N-{3-methyl-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl}-N-phenylpropanamide
Traditional IUPAC Name
3-methylthiofentanyl
SMILES
CCC(=O)N(C1CCN(CCC2=CC=CS2)CC1C)C1=CC=CC=C1
Độ hòa tan
1.80e-02 g/l
logP
4.21
logS
-4.3
pKa (Strongest Basic)
9.07
PSA
23.55 Å2
Refractivity
104.9 m3·mol-1
Polarizability
39.97 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Cơ Chế Tác Dụng : 3-Methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl. 3-Methylthiofentanyl binds to the mu, delta, and kappa opioid receptors. These ultimately lead to decreased pain sensation as well as a number of side effects, such as euphoria, sedation, depressed breathing.
Độc Tính : Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression which can be life-threatening.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01439
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=62296
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506995
ChemSpider
http://www.chemspider.com/Chemical-Structure.56092.html
Wikipedia
http://en.wikipedia.org/wiki/3-Methylthiofentanyl
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