Tìm theo
3-Hydroxy-3-Methyl-Glutaric Acid
hypolipidemic agents
Thuốc Gốc
Small Molecule
CTHH: C6H10O5
PTK: 162.1406
An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H10O5
Phân tử khối
162.1406
Monoisotopic mass
162.05282343
InChI
InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)
InChI Key
InChIKey=NPOAOTPXWNWTSH-UHFFFAOYSA-N
IUPAC Name
3-hydroxy-3-methylpentanedioic acid
Traditional IUPAC Name
meglutol
SMILES
CC(O)(CC(O)=O)CC(O)=O
Độ hòa tan
2.75e+02 g/l
logP
-0.75
logS
0.23
pKa (strongest acidic)
3.68
pKa (Strongest Basic)
-3
PSA
94.83 Å2
Refractivity
34.14 m3·mol-1
Polarizability
14.55 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
-2
Number of Rings
0
Bioavailability
1
Rule of Five
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04377
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1662
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508063
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