Tìm theo
19-norandrostenedione
Các tên gọi khác (3) :
  • 4-estrene-3,17-dione
  • delta4-Estrene-3,17-dione
  • NOR
steroids
Thuốc Gốc
Small Molecule
CAS: 734-32-7
CTHH: C18H24O2
PTK: 272.382
19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency. In the body 19-norandrostenedione is rapidly metabolized into nandrolone, also known as nortestosterone.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H24O2
Phân tử khối
272.382
Monoisotopic mass
272.177630012
InChI
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-16H,2-9H2,1H3/t13-,14+,15+,16-,18-/m0/s1
InChI Key
InChIKey=JRIZOGLBRPZBLQ-QXUSFIETSA-N
IUPAC Name
(1S,2R,10R,11S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,14-dione
Traditional IUPAC Name
19-norandrostenedione
SMILES
[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
Độ hòa tan
4.54e-02 g/l
logP
3.63
logS
-3.8
pKa (strongest acidic)
19.19
pKa (Strongest Basic)
-4.7
PSA
34.14 Å2
Refractivity
79.13 m3·mol-1
Polarizability
31.54 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : 19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency. In the body 19-norandrostenedione is rapidly metabolized into nandrolone, also known as nortestosterone. 19-Norandrostenedione may be metabolized to 19-nortestosterone in both men and women. 19-Norandrostenedione, also known as nandrolone, is the basic substance of some very popular injectable anabolic steroids, however 19-norandrostenedione is not metabolized to testosterone. Whether or not increases in 19-nortestosterone levels would be sustained long enough by taking 19-norandrostenedione to show an increase in nitrogen retention and muscle strength and mass is unknown. 19-Norandrostenedione has also been shown to bind to androgen receptors with high selectivity. Transactivation of androgen receptor dependent reporter gene expression was 10 times lower than that produced by dihydrotestosterone. [1]
Dược Động Học :
▧ Absorption :
Absorption appears variable, but some absorption does occur.
▧ Metabolism :
Specific metabolites of 19-nor-5-androstene-3, 17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone.
Chỉ Định : The claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.
Liều Lượng & Cách Dùng : Powder - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : 19-N-Andro
  • Công ty :
    Sản phẩm biệt dược : Bolandione
  • Công ty :
    Sản phẩm biệt dược : Proven Pure 19-Norandrostenedione
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01434
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=92834
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505377
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C14500
ChemSpider
http://www.chemspider.com/Chemical-Structure.83803.html
Wikipedia
http://en.wikipedia.org/wiki/19-Norandrostenedione
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/19n_0010.shtml
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