Tìm theo
Mitotane
Các tên gọi khác (6 ) :
  • Lysodren
  • Mitotan
  • Mitotane
  • Mitotano
  • Mitotanum
  • Piprine-DDD, O-
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 53-19-0
ATC: L01XX23
ĐG : B&B Pharmaceuticals , http://www.bandbpharmaceuticals.com
CTHH: C14H10Cl4
PTK: 320.041
A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H10Cl4
Phân tử khối
320.041
Monoisotopic mass
317.953661148
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChI Key
InChIKey=JWBOIMRXGHLCPP-UHFFFAOYSA-N
IUPAC Name
1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
Traditional IUPAC Name
mitotane
SMILES
ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl
Độ tan chảy
77 °C
Độ hòa tan
0.1 mg/L (at 25 °C)
logP
6
logS
-6.51
Refractivity
79.97 m3·mol-1
Polarizability
29.93 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
3
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Dược Lực Học : Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.
Cơ Chế Tác Dụng : A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [PubChem] Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
Dược Động Học :
▧ Absorption :
About 40% oral Lysodren is absorbed
▧ Protein binding :
6%
▧ Metabolism :
Hepatic and renal
▧ Route of Elimination :
A variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.
▧ Half Life :
18-159 days
Chỉ Định : For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Tương Tác Thuốc :
  • Acenocoumarol Mitotane may decrease the anticoagulant effect of acenocoumarol.
  • Anisindione Mitotane may decrease the anticoagulant effect of anisindione.
  • Dicoumarol Mitotane may decrease the anticoagulant effect of dicumarol.
  • Spironolactone Spironolactone antagonizes the effect of mitotane
  • Warfarin Mitotane may decrease the anticoagulant effect of warfarin.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Lysodren 500 mg tablet
    Giá bán buôn : USD >5.13
    Đơn vị tính : tablet
  • Biệt dược thương mại : Mitotane powder
    Giá bán buôn : USD >7.75
    Đơn vị tính : g
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00648
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4211
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508319
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00420
ChemSpider
http://www.chemspider.com/Chemical-Structure.4066.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0015-3080-60
PharmGKB
http://www.pharmgkb.org/drug/PA164746157
Wikipedia
http://en.wikipedia.org/wiki/Mitotane
RxList
http://www.rxlist.com/cgi/generic2/mitotane.htm
Drugs.com
http://www.drugs.com/cdi/mitotane.html
... loading
... loading