Tìm theo
Choriogonadotropin alfa
Các tên gọi khác (3) :
  • CG-beta
  • Choriogonadotropin beta chain precursor
  • Chorionic gonadotrophin beta subunit
fertility agents, gonadotropins
Thuốc Gốc
Biotech
CAS: 177073-44-8
ATC: G03GA08
ĐG : EMD Canada Inc. , http://www.emdcanada.com
CTHH: C1105H1770N318O336S26
PTK: 25719.7000
Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C1105H1770N318O336S26
Phân tử khối
25719.7000
Độ tan chảy
55 °C
Độ kỵ nước
-0.258
Điểm đẳng điện tích
8.61
Dược Lực Học : Choriogonadotropin alfa is used to treat female infertility, Choriogonadotropin alfa stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle. Ovidrel is an analogue of Luteinizing Hormone (LH) and binds to the LH/hCG receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge.
Cơ Chế Tác Dụng : Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH. Choriogonadotropin alfa binds to the Follicle stimulating hormone receptor which results in ovulation in the absence of sufficient endogenous Luteinizing hormone.
Dược Động Học :
▧ Absorption :
The mean absolute bioavailability following a single subcutaneous injection to healthy female volunteers is about 40%.
▧ Volume of Distribution :
* 5.9 ± 1.0 L
▧ Route of Elimination :
One-tenth of the dose is excreted in the urine.
▧ Half Life :
The mean terminal half-life is about 29 ± 6 hours (initial half-life is 4.5 ± 0.5 hours).
▧ Clearance :
* 0.29 +/- 0.04 L/h [healthy down-regulated females]
Chỉ Định : For the treatment of female infertility
Liều Lượng & Cách Dùng : Injection, solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00097
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/44087-1150-1
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/J00117
PharmGKB
http://www.pharmgkb.org/drug/PA164783947
Wikipedia
http://en.wikipedia.org/wiki/Choriogonadotropin_alfa
RxList
http://www.rxlist.com/cgi/generic/ovidrel.htm
Drugs.com
http://www.drugs.com/cdi/choriogonadotropin-alfa.html
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