Tìm theo
Capromab
Các tên gọi khác (2) :
  • Capromab pendetide
  • In 111 Capromab pendetide
indicators and reagents, diagnostic agents
Thuốc Gốc
Biotech
CAS: 145464-28-4
ATC: V09IB04
ĐG : EUSA Pharma Inc. , http://www.eusapharma.com
Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Capromab is used to image the extent of prostate cancer.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Độ tan chảy
61 °C (FAB fragment), 71 °C (whole mAb)
Dược Lực Học : Binds to the prostate-specific membrane antigen, which is a cell surface protein generally overexpressed in prostate tissues and prostate cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of PSMA expressing cells and tumors.
Cơ Chế Tác Dụng : Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Capromab is used to image the extent of prostate cancer. Binds selectively to cell-surface prostate-specific membrane antigen (PSMA) expressed on prostate tissues and tumors.
Dược Động Học :

▧ Volume of Distribution :
* 4 ± 2.1 L
▧ Metabolism :
Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production
▧ Route of Elimination :
Approximately 10% of the administered radioisotope dose is excreted in the urine during the 72 hours following intravenous infusion.
▧ Clearance :
* 42 +/- 22 mL/hr
Chỉ Định : For diagnosis of prostate cancer and detection of intra-pelvic metastases.
Tương Tác Thuốc :
  • Buserelin Avoid combination because luteinizing Hormone-Releasing Hormone Analogs may diminish the diagnostic effect of Indium 111 Capromab Pendetide.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Prostascint kit
    Giá bán buôn : USD >1584.0
    Đơn vị tính : kit
Nhà Sản Xuất
  • Công ty : Cytogen Corp.
    Sản phẩm biệt dược : ProstaScint
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00089
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/57902-817-01
PharmGKB
http://www.pharmgkb.org/drug/PA164745489
Wikipedia
http://en.wikipedia.org/wiki/Capromab
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